Mepazine hydrochloride

Research use only, not for human use.

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.

Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.

Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.

——

NF-κB

MALT1

MALT

——

——

2975-36-2

346.92

C19H23ClN2S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (144.13 mM; Ultrasonic )H2O : 2.22 mg/mL (6.40 mM; Ultrasonic (<60°C))

Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4

——

(-20℃)

With Ice Pack

≥ 2 years