
Mepazine hydrochloride
CAS No. 2975-36-2
Mepazine hydrochloride( —— )
Catalog No. M35520 CAS No. 2975-36-2
Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 37 | Get Quote |
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10MG | 53 | Get Quote |
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25MG | 82 | Get Quote |
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50MG | 118 | Get Quote |
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100MG | 168 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameMepazine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.
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DescriptionMepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
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In VitroCell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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In VivoAnimal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
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Synonyms——
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PathwayNF-κB
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TargetMALT1
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RecptorMALT
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Research Area——
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Indication——
Chemical Information
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CAS Number2975-36-2
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Formula Weight346.92
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Molecular FormulaC19H23ClN2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (144.13 mM; Ultrasonic )H2O : 2.22 mg/mL (6.40 mM; Ultrasonic (<60°C))
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SMILESCl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.?
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