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Mepazine hydrochloride

CAS No. 2975-36-2

Mepazine hydrochloride( —— )

Catalog No. M35520 CAS No. 2975-36-2

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 Get Quote
10MG 53 Get Quote
25MG 82 Get Quote
50MG 118 Get Quote
100MG 168 Get Quote
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Biological Information

  • Product Name
    Mepazine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.
  • Description
    Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
  • In Vitro
    Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
  • In Vivo
    Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
  • Synonyms
    ——
  • Pathway
    NF-κB
  • Target
    MALT1
  • Recptor
    MALT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2975-36-2
  • Formula Weight
    346.92
  • Molecular Formula
    C19H23ClN2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (144.13 mM; Ultrasonic )H2O : 2.22 mg/mL (6.40 mM; Ultrasonic (<60°C))
  • SMILES
    Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.?
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