Mepazine hydrochloride

CAS No. 2975-36-2

Mepazine hydrochloride( —— )

Catalog No. M35520 CAS No. 2975-36-2

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 Get Quote
10MG 53 Get Quote
25MG 82 Get Quote
50MG 118 Get Quote
100MG 168 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Mepazine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities.
  • Description
    Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
  • In Vitro
    Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
  • In Vivo
    Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
  • Synonyms
    ——
  • Pathway
    NF-κB
  • Target
    MALT1
  • Recptor
    MALT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2975-36-2
  • Formula Weight
    346.92
  • Molecular Formula
    C19H23ClN2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (144.13 mM; Ultrasonic )H2O : 2.22 mg/mL (6.40 mM; Ultrasonic (<60°C))
  • SMILES
    Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.?
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